Blar i forfatter "Howden, Benjamin P"

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    • Reversible vancomycin susceptibility within emerging ST1421 Enterococcus faecium strains is associated with rearranged vanA-gene clusters and increased vanA plasmid copy number 

      Wagner, Theresa; Janice, Jessin; Schluz, Marc; Ballard, Susan; da Silva, Anders; Coombs, Geoffrey W; Daley, Denise; Pang, Stanley; Mowlaboccus, Shakeel; Stinear, Tim; Hegstad, Kristin; Howden, Benjamin P; Sundsfjord, Arnfinn (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)
      Vancomycin variable enterococci (VVE) are van-positive enterococci with a vancomycin-susceptible phenotype (VVE-S) that can convert to a resistant phenotype (VVE-R) and be selected for during vancomycin exposure. VVE-R outbreaks have been reported in Canada and Scandinavian countries. The aim of this study was to examine the presence of VVE in whole genome sequenced (WGS) Australian bacteremia ...

    • Transiently silent acquired antimicrobial resistance: an emerging challenge in susceptibility testing 

      Wagner, Theresa; Howden, Benjamin P; Sundsfjord, Arnfinn; Hegstad, Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-31)
      Acquisition and expression of antimicrobial resistance (AMR) mechanisms in bacteria are often associated with a fitness cost. Thus, evolutionary adaptation and fitness cost compensation may support the advance of subpopulations with a silent resistance phenotype when the antibiotic selection pressure is absent. However, reports are emerging on the transient nature of silent acquired AMR, describing ...